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Search Results for " t-cell growth factor "

Targets Recommended: Wnt/beta-catenin

4

抑制剂 & 化合物

23

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T39200	β-catenin-IN-37
	β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
T79152	PROTAC EGFR degrader 8	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PROTACEGFRdegrader 8 (T-184) 是一种能够定向降解EGFR的PROTACEGFR降解剂，其在HCC827细胞中的DC50为15.56 nM。该化合物有效抑制多种肺癌细胞系，包括H1975、PC-9和HCC827，其IC50分别为7.72 nM、121.9 nM和14.21 nM。PROTACEGFRdegrader 8 主要用于研究非小细胞肺癌（NSCLC）。
T35940	Darinaparsin Dimethylarsinic glutathione,Darinaparsin
	Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...

化合物

Cat.No: T10904

Target: Wnt/beta-catenin

β-catenin-IN-37

Cat.No: T39200

PROTAC EGFR degrader 8

Cat.No: T79152

Target: EGFR

Cat.No: T35940

Synonym: Dimethylarsinic glutathione,Darinaparsin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01464	IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F) TCGF,Aldesleukin,T-Cell Growt...	Human	HEK293 Cells
	Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages...
TMPJ-01463	IL-2 Protein, Human, Recombinant (E. coli) Aldesleukin,IL-2,IL2,T-Cell Growt...	Human	E. coli
	IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.
TMPJ-00258	TGF beta 2 Protein, Human, Recombinant Glioblastoma-derived T-cell suppr...	Human	HEK293 Cells
	Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be...
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant transforming growth factor β-2,BS...	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPK-00770	IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated Aldesleukin,IL2,白介素,TCGF,T-cell g...	Mouse	HEK293 Cells
	Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. T...
TMPK-00769	IL-2 Protein, Mouse, Recombinant (His & Avi) 白介素,白细胞介素,T-cell growth fact<...	Mouse	HEK293 Cells
	Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted m...
TMPJ-00036	IL-2 Protein, Human, Recombinant (His & Avi), Biotinylated IL2,IL-2,白介素,Interleukin-2,Aldesleukin,T-<...	Human	HEK293 Cells
	IL-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 16-18 KDa and the accession number is P60568.
TMPJ-00877	IL-2 Protein, Rat, Recombinant (His) 白介素,白细胞介素,IL2,Interleukin-2,TCGF,IL-2,...	Rat	HEK293 Cells
	Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine...
TMPJ-00259	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated G-TSF,转化生长因子,Cetermin,Transformin...	Human	HEK293 Cells
	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and the accession number is P61812.
TMPK-00568	IL-9 Protein, Cynomolgus, Recombinant (His) P40,HP40,IL-9,T-cell growth fac	Cynomolgus	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Cynomolgu...
TMPK-00025	IL-9 Protein, Human, Recombinant (hFc) HP40,Cytokine P40,白细胞介素,Interleukin-9,白介素,...	Human	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Human, Re...
TMPK-00026	IL-9 Protein, Mouse, Recombinant (hFc) P40,IL-9,Interleukin-9,Cytokine P40,T<...	Mouse	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Mouse, Re...
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His) Mast cell growth factor,...	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu...
TMPJ-01465	GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) Colony-Stimulating Factor,CSF2,CS...	Human	E. coli
	Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细...	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPY-03439	UBASH3A Protein, Human, Recombinant (aa 354-623, His) TULA,STS-2,CLIP4,ubiquitin associ...	Human	E. coli
	UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A pro...
TMPY-03440	Sts1 Protein, Human, Recombinant (His) STS-1,ubiquitin associated and SH...	Human	E. coli
	UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on...
TMPJ-00456	APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc) TRDL-1,TNFSF13,CD256,TALL-2,A pro...	Mouse	HEK293 Cells
	Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. TNFSF13 is a Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA and plays a role in the regulation of tumor cell growth. It expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissu...
TMPH-02173	TRBC2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...
TMPH-02168	TRAC Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracel...
TMPH-02169	TRBC1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...
TMPJ-00250	LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated transforming growth factor β1,	Human	HEK293 Cells
	Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with ...
TMPY-04399	TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST) DPK,MAP3K18,TAO kinase 3,JIK	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ...

重组蛋白

IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)

Cat.No: TMPJ-01464

Species: Human

Expression System: HEK293 Cells

IL-2 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-01463

Species: Human

Expression System: E. coli

TGF beta 2 Protein, Human, Recombinant

Cat.No: TMPJ-00258

Species: Human

Expression System: HEK293 Cells

TGF beta 2 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00770

Species: Mouse

Expression System: HEK293 Cells

IL-2 Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00769

Species: Mouse

Expression System: HEK293 Cells

IL-2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00036

Species: Human

Expression System: HEK293 Cells

IL-2 Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00877

Species: Rat

Expression System: HEK293 Cells

TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00259

Species: Human

Expression System: HEK293 Cells

IL-9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00568

Species: Cynomolgus

Expression System: HEK293 Cells

IL-9 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00025

Species: Human

Expression System: HEK293 Cells

IL-9 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00026

Species: Mouse

Expression System: HEK293 Cells

IL-3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00051

Species: Mouse

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-01465

Species: Human

Expression System: E. coli

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

Cat.No: TMPY-06981

Species: Human

Expression System: E. coli

UBASH3A Protein, Human, Recombinant (aa 354-623, His)

Cat.No: TMPY-03439

Species: Human

Expression System: E. coli

Sts1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03440

Species: Human

Expression System: E. coli

APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00456

Species: Mouse

Expression System: HEK293 Cells

TRBC2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02173

Species: Human

Expression System: E. coli

TRAC Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02168

Species: Human

Expression System: E. coli

TRBC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02169

Species: Human

Expression System: P. pastoris (Yeast)

LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00250

Species: Human

Expression System: HEK293 Cells

TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)

Cat.No: TMPY-04399

Species: Human

Expression System: Baculovirus Insect Cells

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